Ayowale Aladejana, 26, died at the scene in Monson Road, New Cross, southeast London, on 2 August after police were called to reports of a man with stab wounds at a residential address.
Ben Wazabanga and Ronique Belfon, both 23 and from Bedford, were arrested and charged with murder. Wazabanga was also charged with possession of a knife.
Both appeared at the Old Bailey on Wednesday, with Belfon appearing via a video-link from HMP Bronzefield.
During their first crown court appearance, prosecutor Ben Holt told the court: “This would appear to be a targeted attack on the victim.
“Both defendants travelled some distance with two small children in the car to carry out the attack.”
Mr Holt also told the court that the incident was captured on a Ring doorbell video camera and that before the incident, the defendants’ car had allegedly circled the address a number of times.
Prosecutors said that Wazabanga and Belfon had two children in the back of their car at the time, and had travelled around 50 miles to the property.
The court heard Wazabanga – a Belgian national – then allegedly approached the victim’s home, before Mr Aladejana was said to have opened his door and said: “Brother, why you coming to my home?”
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Following an exchange, it is alleged that Wazabanga stabbed Mr Aladejana once in the chest before the defendants drove off.
Wazabanga and Belfon spoke only to confirm their identities before Judge Lynn Tayton KC set a timetable for the case.
A plea hearing will take place on 23 October. A trial lasting four weeks has been provisionally scheduled for 13 April next year.