Should Wales and Northern Ireland win, they will play each other tie for a place at the finals in North America next summer.
If the Republic of Ireland, who booked their spot in dramatic fashion thanks to a last-gasp victory over Hungary, get past the Czechs, they will take on either Denmark or North Macedonia.
Northern Ireland, who qualified through the Nations League, have the toughest task of the three – at least on paper – against the Azzurri, who have won the tournament four times.
Wales, who ended their qualifying campaign with a thumping 7-1 victory over North Macedonia, will be trying to reach their second finals in a row and their third overall.
Northern Ireland have appeared in world football’s biggest tournament three times, the last in 1986.
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